电针及针药结合对PD大鼠行为学及DA含量的影响

Effect of Electroacupuncture and Madopar on Rotational Behavior and the Content of Dopamine in PD Rats

[目的]观察电针及针药结合对帕金森病大鼠的行为学指标的影响,及其对纹状体内多巴胺含量的影响。[方法]纹状体内注入6-OHDA制作PD大鼠模型。将大鼠随机分为假手术组、手术组,将造模成功的手术组大鼠随机分为电针治疗组、美多巴治疗组、针药结合组、模型对照组。检测各组实验大鼠的旋转行为,并通过高效液相电化学法测定各组实验大鼠纹状体内多巴胺含量。[结果]对各组实验大鼠行为学检测及脑纹状体内多巴胺的含量检测结果显示,与模型对照组及假手术组比较,各治疗组差异显著(P<0.05);各治疗组间比较无差异。[结论]说明电针疗法、、针药结合疗法有与口服美多巴相似的疗效,可以有效提高纹状体内DA的含量,改善帕金森病大鼠的旋转行为。

[Objective] Observing the effect of the electroacupuncture on the rotational behavior and the content of dopamine in striatum to approach therapeutic effect.[Methods]The rat model of PD was made by injecting the 6-hydroxy dopamine into the striatum from four points.The rats were measured the rotational behavior and detected content of dopamine in the striatum by HPLC-ECD.[Results]The curative effect was good contrasted with the control group.[Conclusion]EA increased concentration of dopamine in the striatum obviously,improved the rotational behavior,which could control the development of PD like the role of Madopar.