高嘌呤食饵诱发雌性鹌鹑高尿酸血症模型病理特征的系统研究

Systemic Study on Model Female Quail Pathological Characteristics of Hyperuricemia(HUA) Caused by High-purin Food

[目的]动态观察造模280d期间雌性鹌鹑高尿酸血症(HUA)模型的病理特征。[方法]选择迪法克品系雌性鹌鹑30只,按体重随机分为对照组和模型组,每组15只。高嘌呤食饵喂饲280d,定期检测血清尿酸(UA)、甘油三酯(TG)、血糖(GLU)、低密度脂蛋白(LDL)、总胆固醇(TC)等指标。并与对照组比较。[结果]高嘌呤食饵喂饲雌性鹌鹑280d期间,高UA水平持续稳定;随着造模时间延长,模型动物可伴发糖、脂代谢紊乱,并出现肝、肾功能损伤的病理表现。[结论]该方法制造的高尿酸血症模型稳定。

[Objective] To dynamically observe pathological feature of female quail HUA.[Method] Select 30 quails;randomly divide them into control and model groups by weight,15 in each one.Take high-purin food for 280d,periodically measure UA,TG,GLU,LDL and TC,compare them between both groups.[Result] The UA level is stable continually;with modeling time passing,the model animals have pathological symptoms glucose and lipid metabolism,also injury of liver and kidney.[Conclusion] The method has stable model of hyperuricemia.