血清β-淀粉样蛋白和血管紧张素转化酶联合检测对血管性认知功能障碍疾病的诊断价值探讨

Application of serum β-amyloid protein and angiotensin-converting enzyme combined detection in the vascular cognitive disorders.

目的探讨血管性认知功能障碍疾病患者血清β-淀粉样蛋白和血管紧张素转化酶的含量变化及其临床意义。方法采用双抗体夹心酶联免疫吸附法(ELISA)测定30例血管性认知功能障碍患者(观察组)、31例其它系统疾病患者(对照组)及28例健康人血清中β-淀粉样蛋白(β-Amy-loid)和血管紧张素转化酶(ACE)含量。结果血清中β-Amyloid含量疾病组高于对照组和健康组,差异有统计学意义(P<0.05);对照组与健康组比较差异无统计学意义(P>0.05);疾病组患者血清中β-Amyloid含量随年龄增大有增高趋势,但经统计学分析与年龄无相关关系(P>0.05);轻、中、重度疾病患者间血清β-Amyloid含量差异无统计学意义(P>0.05)。ACE含量疾病组低于对照组和健康组,差异有统计学意义(P<0.05);对照组与健康组比较差异无统计学意义(P>0.05)。直线相关回归分析发现血清中β-Amyloid和ACE无相关关系,(r=0.041,P>0.05)。结论血清中β-Amyloid和ACE含量的改变与认知功能障碍疾病发生有密切关系,联合检测两项指标可能成为临床诊断的途径。

Objective To search for the clinical significance and changes of serum β-amyloid levels and angiotensin converting enzyme in patients with cognitive impairment of vascular disease.Methods By double antibody sandwich enzyme-linked immunosorbent assay(ELISA) measured 30 patients with vascular cognitive impairment patients which was observation group and 31 patients with other diseases patients which was control group,and 28 healthy human serum β-amyloid protein(β-Amyloid) and angiotensin converting enzyme(ACE...