纳洛酮治疗慢性阻塞性肺疾病Ⅱ型呼吸衰竭患者脑电图异常的疗效研究

Study on Efficacy of Naloxone with Electroencephalogram Disorder in Patients with COPD and Type Ⅱ Respiratory Failure

目的:研究纳洛酮治疗慢性阻塞性肺疾病(COPD)Ⅱ型呼吸衰竭患者脑电图异常的疗效。方法:141例COPDⅡ型呼吸衰竭且脑电图异常者随机分为2组,试验组71例,给予纳洛酮2mg每日1次静脉滴注;对照组70例,给予尼可刹米1.125g和洛贝宁9mg每日1次静脉滴注,疗程均为7d,对比2组治疗前、后脑电图及动脉血气分析变化。结果:试验组在纠正缺氧、减少二氧化碳潴留方面较对照组改善显著(P=0.01,P=0.02);试验组与对照组脑电图改善有效率分别为85.9%、67.1%,差异有统计学意义(P=0.008)。结论:纳洛酮组治疗COPDⅡ型呼吸衰竭患者后脑电图好转优于对照组,效果显著,未发现不良反应。

OBJECTIVE: To study the efficacy of naloxone with electroencephalogram (EEG) disorder in patients with chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure. METHODS:141 patients with COPD and type Ⅱ respiratory failure were randomly divided into two groups:71 cases in treatment group and 70 cases in control group. In treatment group, naloxone 2 mg was administered by intravenous infusion once a day while in control group nikethamide 1.125 g and lobeline 9 mg were also administered by ...