硫普罗宁序贯疗法治疗慢性乙型肝炎的最小成本分析

Cost-minimization Analysis of Sequential Therapy of Tiopronin in the Treatment of Chronic Hepatitis B

目的:评价硫普罗宁2种方案治疗慢性乙型肝炎的经济学效果。方法:90例慢性乙型肝炎患者分别应用硫普罗宁序贯疗法(治疗组)、单纯应用注射用硫普罗宁(对照组)治疗,观察2组疗效及不良反应,并采用最小成本分析法进行药物经济学分析。结果:治疗组与对照组的有效率分别为86.67%、84.44%(P>0.05),不良反应发生率均为4.44%,成本分别为1183.5、1998.0元(P<0.05)。结论:硫普罗宁序贯疗法是治疗慢性乙型肝炎的较佳方案。

OBJECTIVE:To evaluate the pharmacoeconomic efficacy of two therapeutic schemes of tiopronin in the treatment of chronic hepatitis B.METHODS:90 patients with chronic hepatitis B were divided into 2 groups.One group took the sequential therapy of tiopronin(treatment group) and the other took the pure tiopronin for injection(control group).Therapeutic efficacy and ADRs were observed and a cost-minimization analysis was performed for the 2 groups.RESULTS:The effective rate of 2 groups was 86.67% and 84.44%(P>...