自噬的分子医学研究进展

Prospective of Autophagy Involved in Molecular Medicine

自噬是指细胞内的溶酶体降解自身细胞器和其他大分子的过程,是一种高度保守的细胞内蛋白质再循环机制,能够导致程序性细胞死亡,又称为Ⅱ型细胞死亡。饥饿、缺氧、细胞内应激、激素或生长发育信号等均可诱导产生。越来越多的证据表明自噬参与许多心血管疾病的进展与保护作用,能够清除受损的蛋白质和细胞器以避免产生细胞毒性或诱发细胞凋亡。本文主要讨论自噬的研究进展及与肿瘤和心血管疾病的关系。

Autophagy is a highly conserved cellular mechanism of protein recycling that can lead to programmed cell death (type II programmed cell death). Autophagy can be induced by starvation, hypoxia, intracellular stress, hormones, or developmental signals. Emerging evidence reveals that autophagy is involved in the progression or prevention of cardiovascular diseases. Autophagy can eliminate damaged proteins and organelles that might otherwise be toxic or trigger apoptotic death. In this review, we focus on the p...