摘要
目的探讨雌激素受体(ER)基因多态性与云南多发性硬化(MS)女性病人的相关性。方法应用限制性片段长度多态性聚合酶链反应(RFLP-PCR)分析方法,检测24例MS女性患者和30例性别、年龄相匹配的健康对照者ER基因PvuⅡ和XbaⅠ酶切多态性。结果 MS组P等位基因频率与对照组相比差异有显著性(X2=4.296,P<0.05);X等位基因在两组间比较无显著性(X2=0.665,P>0.05);联合基因分析,两组间其基因型频率分布差异无显著性(X2=6.073,P>0.05)。结论 ER基因PvuⅡ酶切多态性与MS具有相关性,可能是云南汉族女性发病的危险因素之一;XbaⅠ酶切多态性与MS无相关性。
Objective To explore the correlation ship between estrogen receptor(ER) gene polymorphism and multiple sclerosis(MS)in female patients of Yunnan Han.Methods ER genotypes were performed in 24 female with MS and 30 controls by RFLP-PCR.Results The distribution frequencies of P alletic gene in MS group and control group were 45.8% and 26.7%,respectively,which had signifecent difference(X2= 4.296,P< 0.05);while the distribution frequencies of X alletic gene in MS group and control group were 22.9% and 16.7%,...
出处
《脑与神经疾病杂志》
2011年第2期138-140,共3页
Journal of Brain and Nervous Diseases
关键词
雌激素受体
基因多态性
多发性硬化
Estrogen receptor
Gene polymorphism
Multiple sclerosis（MS）
