血浆同型半胱氨酸与脑梗死及颈动脉粥样硬化相关性的研究

Study on relation between piasma level of homocysteine and cerebral infarction as well as carotid artery atherosclerosis

目的探讨同型半胱氨酸水平与脑梗死、颈动脉粥样硬化的关系。方法将508例分为脑梗死组368例和对照组140例,测定血浆同型半胱氨酸水平与糖尿病、高血压、年龄、性别、血脂等各指标间的关系;同时做颈动脉彩色多普勒超声检查,比较脑梗死组与对照组、颈动脉硬化组与颈动脉正常组同型半胱氨酸水平变化。结果脑梗死组与对照组血浆同型半胱氨酸水平升高分别为309例和23例,各占84.2%和16.4%,同型半胱氨酸水平分别为(25.33±5.66)umol/L和(12.52±3.16)umol/L,两组比较有统计学意义(P<0.001)。脑梗死组中伴颈动脉粥样硬化的患者血浆同型半胱氨酸水平明显高于颈动脉正常者(P<0.001)。结论高同型半胱氨酸血症是脑梗死独立的危险因素,与颈动脉粥样硬化及斑块形成有关。

Objective To investigate the relationship between plasma level of homocysteine(Hcy) and cereral infarction as well as carotid artery atherosclerosis(AS).Methods 368 patients were enrolled as ISH group and 140 non-ISH patients as control group.The plasma level of Hcy were measured in all subjects.The relations between Hcy and diabetes,hypertension,age,sex,blood lipid were analyzed.All carotid arteries of all patients were examined with colour Doppler ultrasound.The concentration of Hcy were compared in cereb...