靶向给药系统的体内药物动力学分析

Study on Pharmacokinetics Model for Targeted Drug Delivery Systems

建立靶向给药系统的体内药物动力学模型。以房室模型理论为依据,结合质量守恒原理,建立了数学模型,推导出了靶器官的药时函数表达式,并用实验数据验证了其准确性。根据所得靶器官的药时函数表达式,用统计矩方法分析了靶向给药系统的靶器官药物动力学规律,给出了靶器官的药物动力学参数。结果表明:靶器官中的药时函数表达式与实验数据能很好地拟合。我们所建立的药时函数表达式能很好地刻画靶向制剂体内药物动力学规律。

To establish the mathematical model for targeted drug delivery systems.The mathematical models for targeted drug delivery systems were developed based on compartment theory and mass conservation theory.The function formulas of drug concentration-time in target organ was established.Based on the target organ drug concentration-time curve,the pharmacokinetics parameters of the target organ could be calculated by the statistical moment.We further detected the practicability of the models by using the experimental data of drug concentration-time curve in target organ of microspheres.The drug concentration-time curve in target organ predicted by mathematical model was agreed with that observed.The established model is useful to describe the pharmacokinetics process in vivo.