FAK和FAKpY397在喉癌中的表达及意义

Expression and significance of FAK and FAKpY397 in squamous cell carcinoma of larynx

目的检测黏着斑激酶(FAK)及磷酸化黏着斑激酶(FAKpY397)在喉鳞状细胞癌中的表达及临床病理意义。方法采用免疫组织化学方法检测57例喉鳞状细胞癌和10例正常喉部组织中FAK及FAKpY397的表达。结果 57例喉鳞状细胞癌中FAK与FAKpY397阳性表达率分别为66.7%和84.4%,与正常喉组织相比差异有统计学意义(P<0.01)。FAK、FAKpY397与肿瘤的临床分期和淋巴结转移有关(P<0.05),与患者年龄、肿瘤大小及分化程度无明显相关。结论 FAK和FAKpY397在喉癌中有高表达,推测与喉癌的侵袭及转移相关。

Objective To detect the expression and clinicopathological significance of focal adhesion kinase(FAK) and phosphorylation of focal adhesion kinase tyrosine 397(FAKpY397) in human squamous cell carcinoma of larynx. MethodsThe expression of FAK and FAKpY397 in tissues of squamous cell carcinoma of larynx(n=57) and normal laryngeal tissues(n=10) was detected by immunohistochemistry. Results The positive expression of FAK and FAKpY397 was 66.7% and 84.4%,respectively in tissues of squamous cell carcinoma of larynx,and was significantly different from that of normal laryngeal tissues(P<0.01).The expression of FAK and FAKpY397 was correlated with the clinical stage and lymph node metastasis(P<0.05),but was not related to the age of patients,tumor size and degree of differentiation of carcinoma cells.Conclusion There is high expression of FAK and FAKpY397 in tissues of squamous cell carcinoma of larynx,which may be related to the invasion and metastasis of squamous cell carcinoma of larynx.