内皮祖细胞在经皮冠状动脉介入治疗后内皮损伤修复中的作用

Roles of endothelial progenitor cells in endothelial regeneration after vascular injury associated with percutaneous coronary intervention

经皮冠状动脉介入治疗(PCI)显著地改善了冠心病患者的心肌供血和临床预后。虽然冠状动脉内支架设计已得到不断改进,支架术后强效抗血小板药物治疗也越来越普及,但是PCI术后并发症的发生率仍然较高。内皮再生是PCI导致血管损伤反应的重要组成部分。新近研究发现,内皮祖细胞(EPC)可以通过再内皮化促进血管修复,从而在血管损伤反应中起到重要作用。PCI内皮损伤后循环EPCs的作用可能成为促进内皮修复的一种新的治疗措施。因此,深入了解EPC的生物学特性及它在PCI相关的血管损伤中的作用机制将为介入并发症的治疗提供一种新的思路。

Percutaneous coronary intervention(PCI) has significantly improved myocardial perfusion and clinical outcomes in patients with ischemic heart diseases in recent years.Adverse cardiac events after PCI continue to be problematic despite advances in stent design and adjunctive pharmacotherapy.Endothelial regeneration is a key component of an effective response to vascular injury associated with PCI.Endothelial progenitor cells(EPCs) recently emerged as an important component of response to vascular injury,having the potential to accelerate vascular repair through rapid re-endothelialization.The roles of circulating EPCs in response to vascular injury may serve as effective strategies to enhance vascular repair after PCI.The elucidation of biological characteristics of EPCs and mechanism of EPCs in PCI-associated vascular injury may help to develop an effective treatment modality to manage the complications associated with PCI.