翼螺旋转录因子Foxa2与糖脂代谢及糖尿病关系的研究进展

Research progress of relationship between forkhead transcription factor Foxa2 and glucose and lipid metabolism and diabetes mellitus

翼螺旋转录因子Foxa2是调节胰腺发育及糖、脂代谢的重要转录因子。作为胰岛素信号的下游靶标,大脑中Foxa2的结构性激活,引起食物消耗、代谢及胰岛素敏感性增加。Foxa2参与葡萄糖和脂质代谢通路的基因表达调节,改善外周组织胰岛素抵抗,是新的胰岛素敏感性转录调节因子;该蛋白的磷酸化通过细胞定位改变而引起失活。该文就Foxa2与糖脂代谢及糖尿病关系的研究进展进行综述。

Forkhead transcription factor Foxa2 is an important transcription factor regulating pancreatic development and glucose and lipid metabolism.As a downstream target of insulin signaling,constitutive activation of Foxa2 in the brain results in increased food consumption,metabolism and insulin sensitivity.Foxa2 regulates gene expression involved in glucose and lipid metabolism pathway,improves insulin resistance in peripheral tissues,and has been recognized as a novel transcription factor of insulin sensitivity.Phosphorylation of the protein results in Foxa2's inactivation by its localization changing from nuclei to cytosol.The research progress of relationship between Foxa2 and glucose and lipid metabolism and diabetes mellitus is reviewed in this paper.