饮茶与卵巢癌患病风险相关的Meta分析

Meta-analysis of correlation between tea consumption and risk of ovarian cancer

目的通过Meta分析研究饮茶与卵巢癌患病风险的相关性。方法在Pubmed、EMbase、CBMdisc、CNKI、万方数据库检索相关文献,建立一定的筛选标准,在群体研究中探究卵巢癌发病风险与饮茶的关系。检索年限为1995—2010年,采用RevMan5.1.0软件完成Meta分析。结果共纳入国内外病例对照试验和队列试验9项研究,包括69 786例参与者,其中病例4 571例,对照65 215例。Meta分析显示:饮用茶可以显著地降低女性患卵巢癌的风险(RR=0.82,95%CI=0.70~0.96,P<0.001);其中绿茶降低患病风险的作用更为显著(RR=0.69,95%CI=0.54~0.90,P=0.006)。结论饮用茶可以在一定程度上降低女性卵巢癌的患病风险,其中绿茶的抗癌效果更为显著。

Objective To explore the correlation between tea consumption and risk of ovarian cancer through Meta-analysis.Methods Relative studies published between 1995 and 2010 about tea consumption and risk of ovarian cancer were searched in Pubmed,EMbase,CBMdisc,CNKI and Wanfang Data.All reports were systemically reviewed,and Meta-analysis was performed by RevMan 5.1.0 software.Results A total of 9 domestic and overseas case-control studies and cohort studies were included,with 4 571 cases and 65 215 controls.Meta-analysis revealed that tea consumption significantly decreased the risk of ovarian cancer(RR,0.82;95%CI,0.70-0.96;P<0.001),and the effect was more significant for green tea consumption(RR,0.69;95%CI,0.54-0.90;P=0.006).Conclusion Tea consumption,especially green tea consumption,may reduce the risk of ovarian cancer.