肿瘤相关抗原OVA66在人肿瘤组织中的表达

Expression of tumor-associated antigen OVA66 in human tumor tissues

目的分析肿瘤相关抗原OVA66在人肿瘤组织中的表达特征,探讨其临床应用价值。方法采用免疫组织化学法检测多种组织肿瘤芯片和肿瘤组织标本(包括胃癌、肠癌、肺癌、乳腺癌、膀胱癌、肾癌和卵巢癌)及其相应的非肿瘤组织中OVA66蛋白的表达,分析其表达与组织的良恶性以及肿瘤转移和临床病理特征的关系。结果 OVA66蛋白在胃、肠、卵巢、膀胱和肾的肿瘤组织中的表达显著高于正常组织,在肺和乳腺肿瘤组织中表达较弱。膀胱癌OVA66的表达与膀胱癌的病理分级呈现相关性,肠癌和膀胱癌的淋巴转移组表达阳性率略高于未转移组,但差异无统计学意义。结论 OVA66蛋白在多数肿瘤组织中均呈高表达,在膀胱癌中与肿瘤病理分级相关,提示OVA66有可能成为新的肿瘤标志物应用于多种肿瘤的辅助诊断。

Objective To investigate the expression of tumor-associated antigen OVA66 in human tumor tissues,and explore its clinical values. Methods Immunohistochemistry was employed to detect the expression of OVA66 protein in several types of tumor tissue chips and samples(gastric cancer,intestinal cancer,lung cancer,breast cancer,ovarian cancer,bladder cancer and renal cancer) and corresponding non-tumor tissues.The relationship between the expression of OVA66 protein and character of tumor tissues,tumor metastasis and clinicopathological characteristics was analysed.Results There was high expression of OVA66 protein in the tumor tissues of stomach,intestine,ovary,bladder and kidney,which was significantly higher than that in non-tumor tissues.While the expression of OVA66 was relatively lower in the tumor tissues of lung and breast.The expression of OVA66 in bladder cancer tissues was related to the pathological grading of bladder cancer.The expression of OVA66 in intestinal cancer and bladder cancer with lymph node metastasis was slightly higher than that in intestinal cancer and bladder cancer without lymph node metastasis,while there was no significant difference between them. Conclusion There is high expression of OVA66 protein in many tumor tissues.The expression of OVA66 protein in bladder cancer tissues is related to the pathological grading of bladder cancer.OVA66 may serve as a novel tumor marker in the diagnosis of tumors.