颅内动脉瘤患者主动脉弹性功能变化及临床意义

Aortic elastic properties and its clinical significance in intracranial aneurysms

目的:观测颅内动脉瘤患者的主动脉弹性功能,探讨其功能变化的临床意义。方法:选择107例颅内动脉瘤患者(其中伴发高血压者57例)和108例正常对照者,M型超声心动图测量升主动脉收缩期(AoS)及舒张期(AoD)内径,计算并比较各组主动脉弹性功能指标。结果:①与正常对照组比较:颅内动脉瘤高血压组、非高血压组患者的主动脉膨胀性(aortic distensibility,DIS)均明显降低(P<0.001),而僵硬度(aortic stiffness index,SI)明显增加(P<0.001)。②与颅内动脉瘤非高血压组比较,伴有高血压的颅内动脉瘤患者DIS明显降低(P<0.001),而SI有所升高(P<0.05)。三组间经体表面积、体重指数校正后的校正值亦存在同样规律。结论:颅内动脉瘤患者均存在主动脉弹性功能的减退,且高血压是引起该疾患主动脉弹性功能进一步减退的原因之一。

Objective: To investigate the aortic elastic properties and its clinical significance in intracranial aneurysms(IAs). Methods: One hundred and seven IAs patients(57 with hypertension) and 108 healthy subjects were recruited.The internal aortic diameters in systole and diastole were measured by the M-mode echocardiography,the aortic elasticity indexes were calculated and compared. Results: The aortic distensibility(DIS) was lower and the aortic stiffness index(SI) was higher in IAs patients than those in controls(both P<0.001).DIS was lower and SI was higher in IAs patients with hypertension(IAs-HP) than those in IAs with no hypertension(P<0.001).Similar results were obtained when the aortic elasticity index were adjusted for body surface area and body mass index. Conclusion: Abnormal aortic elasticity is a common finding in IAs patients and hypertension is closely related to the severity of aortic elasticity.