低氧细胞应激的HIF-1信号通路

HIF-1 signal pathway in cellular response to hypoxia

低氧诱导因子(hypoxia inducible factor,HIF)由HIF-1α和HIF-1β两个亚基组成,在低氧下其能激活多种靶基因的转录,在细胞、组织生长发育和生理应激,以及某些病理过程中具有重要的作用。近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因转录调控的研究取得了巨大进展。

HIF-1 is composed of HIF-1α and HIF-1β subunits.It promotes target genes transcription under hypoxia and plays essential roles in cell development,physiological adaptations,and pathological processes.In the past 10 years,the research on signaling pathways of HIF-1 in response to cell hypoxia stress,especially on HIF-1α-mediated gene transcription has made great progress.