摘要
以L-半胱氨酸盐酸盐为起始原料,在氧化-还原体系催化下与烯丙醇发生反应,制得祛痰药福多司坦,总收率达到91%.目标化合物的结构经1H-NMR,IR确证.与文献相比,该法操作简单,收率高,适合工业化生产.
Expectorant fudosteine is synthesized from L-cysteine hydrochloride using oxidation-reduction system catalyst with an overall yield of about 91%.The structure of the target product is characterized by 1H-NMR and IR.The method has the advantages of simple and hihger yields,which is suitable for industrialization.
出处
《河南师范大学学报(自然科学版)》
CAS
CSCD
北大核心
2011年第3期103-104,共2页
Journal of Henan Normal University(Natural Science Edition)