芪参益气滴丸及其组成中药抗缺血再灌注损伤的研究进展

Progress of Qishenyiqi Dripping Pill on Clinical and Experiment Study

目的:了解芪参益气滴丸临床和实验研究概况,为深入研究该方作用机制提供借鉴。方法:检索芪参益气滴丸的临床和实验文献,以及芪参益气滴丸组成中药对心肌缺血再灌注损伤作用的文献,归纳总结芪参益气滴丸主要临床作用及可能的药理机制与配伍规律。结果:芪参益气滴丸临床主要应用于多种心血管疾病的治疗,并获得较好的临床疗效,少量报道应用于特发性肺纤维化、慢性乙型肝炎等治疗;药理机制的研究主要集中在以急性心肌缺血为动物模型进行研究;芪参益气滴丸4味配伍中药单独应用对心肌缺血再灌注损伤模型均有一定影响,并有一些相似的分子生物学机制。结论:芪参益气滴丸临床对多种心血管疾病确有疗效,其作用机制研究也取得了一定进展,但仍有很多不确定的地方需要深入研究。

Object:To Comprehend Progress of Qishenyiqi Dripping Pill on Clinical and Experiment Study for lucubrating its mechanism of action.Methods: Summary of main clinical effect and pharmacological mechanism and combinative regularity of Qishenyiqi formula on Cardiac ischemia and reperfusion through documents study.Result: Qishenyiqi Dripping Pill is applied to treat diverse cardiovascular diseases,gain better clinical effect,a few report about treating idiopathic pulmonary fibrosis,Chronic Hepatitis B and so on.The animal model for its pharmacological mechanism study is main acute myocardium ischemia.The four components of Qishenyiqi Dripping Pill have also some influence to the model of myocardium ischemia reperfusion injury.There are some similar molecular biology mechanism.Conclusion: Qishenyiqi Dripping Pill have certain therapeutic effect to diverse cardiovascular diseases.There are a certainly progress on its mechanism,but still to remain many uncertainly points need to evolve more deeply research.