抗环瓜氨酸肽抗体在类风湿关节炎诊断中的应用

Anti-cyclic Citrullinated Peptide Antibodies in Patients with Rheumatoid Diagnosis

目的比较抗环瓜氨酸肽抗体(抗-CCP)、类风湿因子(RF)在类风湿性关节炎(RA)诊断中的应用价值。方法对54例(RA24例、非RA30例)患者及正常对照20例血清同时进行抗-CCP、RF检测,检测方法分别为酶联免疫吸附试验(ELISA)、胶乳凝集试验。结果 RA组中两种抗体的阳性率高于非RA组(P<0.01);抗-CCP对RA诊断的敏感性(79.1%)与RF(87.5%)的差异无统计学意义(P>0.05);抗-CCP对RA诊断的特异性(96%)明显高于RF(72%)(P<0.01)。结论抗-CCP有适度的敏感性和很高的特异性,对诊断RA具有较好的应用价值;联合检测抗-CCP和RF具有更高的敏感性。

Objective To compare the diagnostic value of anti-cyclic citrullinated peptide antibodies(anti-CCP),rheumatoid factor (RF) in rheumatoid arthritis(RA).Methods Anti-CCP antibodies and RF of 54 cases(RA 24 cases,non-RA 30 cases) and 20 normal controls were detected at the same time,by enzyme linked immunosorbent assay(ELISA) and latex agglutination test.Results The-positive rates of two kinds of antibody was significantly higher than non-RA group(P<0.01).There was no significant difference between anti-CCP(79.1%) and RF(87.5%) for the diagnosis of RA sensitivity(P>0.05).The diagnosis specificity of anti-CCP antibodies(96%) was significantly higher than the RF(72%)(P<0.01).Conclusion Anti-CCP antibodies have a moderate sensitivity and high specificity in the diagnosis of RA and has a good application value;combined with the detection of anti-CCP antibody and RF,the sensitivity will be higher.