摘要
20世纪90年代以来,随着联用技术和基因研究的发展,生物大分子药物的研究深受化学和医学工作者的关注,成为研究热点之一。本文综述了表面等离子共振-环伏安法(SPR-CV)、生物分子相互作用分析-质谱法(BIA/MS)、微流路芯片毛细管电泳-质谱法(Chip-CE-MS)、离线二维液相色谱综合串联质谱法(2D-LC coupled MS/MS)及液相色谱-质谱-核磁共振(LC-MS-NMR)联用技术在生物大分子药物中的研究应用进展。这些联用技术的应用将为生物大分子药物的研究开发开拓广阔的前景。
Since the 1990s,following the development of new combined techniques and gene research,the biomacromolecule drugs were concerned by chemical and medical workers.Now,this subject has become a research hotpot.In this paper,the progress on studies and applications of some modern combined techniques in biomacromolecule drugs are reviewed,including surface plasmon resonance-cyclic voltammetry(SPR-CV),biomolecular interaction analysis-mass spectrometry(BIA/MS),microfluidics chip capillary electrophoresis-mass spectrometry(Chip-CE-MS),two-dimensional liquid chromatography coupled to tandem mass spectrometry(2D-LC coupled MS/MS) and LC-MS-NMR.The applications of these new combined techniques will open up broad prospect for the research and development of biomacromolecule drugs.
出处
《食品与药品》
CAS
2011年第5期209-212,共4页
Food and Drug
关键词
近代联用技术
生物大分子药物
应用
modern combined techniques
biomacromolecule drugs
applications
