DNA甲基化与肿瘤

DNA methylation and tumor

DNA甲基化是最早发现的基因修饰途径之一,可引起染色质结构、DNA构象、DNA稳定性及DNA与蛋白质相互作用方式的改变,控制基因表达。肿瘤中普遍存在DNA甲基化状态的改变,DNA甲基化在肿瘤的发生发展中的作用是当前的研究热点。

DNA methylation,one of the earliest found modification ways control the gene expression through changing chromatin structer,DNA conformation,DNA stability and DNA-protein interaction.The changes of DNA methylation status are discovered in tumor.Therefore,the role of DNA methylation in the tumor's occurrence and development is becoming a hot spot of study in current.