国内呼吸康复研究的荟萃分析

Lung Rehabilitation in Chronic Respiratory Diseases in China:A Meta-Analysis

目的对国内呼吸康复的现状进行分析,并用荟萃分析的方法探讨呼吸康复对慢性呼吸系统疾病的影响。方法主要检索中国学术期刊网全文数据库(CNKI)、中国科技期刊数据库及万方数据检索系统三个数据库,收集国内发表的呼吸康复研究论文进行汇总,纳入随机对照临床研究。从每项研究中提取相关数据,包括研究人群、呼吸康复干预方法、康复评定方法等。并用RevMan 4.2软件对文献进行系统分析,采用2值和P值分析各研究结果的统计学异质性。结果共有3项研究符合纳入标准,入选病例均为重度及极重度慢性阻塞性肺疾病(COPD)患者。呼吸康复能改善重度及极重度稳定期COPD患者的日常活动能力(WMD:1.29,95%CI:1.05~1.54)及呼吸困难程度(SMD:-1.27,95%CI:-1.67^-0.86)。结论国内呼吸康复的总体水平不高,目前的研究支持呼吸康复能改善重度及极重度稳定期COPD患者的呼吸困难程度和日常活动能力。

Objective To review the current state of lung rehabilitation in China and explore the effect of lung rehabilitation on chronic respiratory diseases.Methods Database of CNKI(1979-2009),VIP Chinese Periodical Database(1989-2009),and Wanfang Data(1982-2009) resources were searched.Studies of lung rehabilitation were collected,and randomized and controlled trials were included.Data were extracted on study population,interfering and evaluating methods.The meta-analyses were performed by using RevMan 4.2 software.The heterogeneity was analyzed by x2 and P value.Results A total of 3 clinical trials met the inclusion criteria.The study population were all severe and very severe chronic obstructive pulmonary diseases(COPD) patients.Lung rehabilitation could improve daily activity(WMD:1.29,95%CI:1.05-1.54) and dyspnea level(SMD:-1.27,95%CI:-1.67 to-0.86) of COPD patients.Conclusion The general level of studies on lung rehabilitation is not satisfied.Meta-analysis comfirmes that lung rehabilitation is beneficial in improving daily activity and dyspnea level of COPD patients.