高危型人乳头瘤病毒与子宫颈病变相关因素的探讨

Probe into the relationship between high-risk HPV and cervical dysphasia clinic

目的研究妇女生殖道感染高危型人乳头瘤病毒(HR-HPV)的载量与子宫颈病变的关系。方法收集参加横断面普查研究的3567名18～69岁已婚或有性生活史的体检女性患者的宫颈外口及宫颈管分泌物,采用第二代杂交捕获试验(HC2)进行HPVDNA检测,高危阳性者均要求其进行阴道镜活组织检查,通过随诊对照其细胞学与组织学结果,探讨该技术在宫颈病变中的应用价值。结果 3567名检查对象中,高危型HPV感染者为88例,经阴道镜活组织检查,正常者34例(39%),异常者为54例(61%)。结论高危型HPVDNA检测是子宫颈疾病筛查的有效手段,其与子宫颈病变程度呈正相关。

Objective To find out the relationship between cervical lesions and the viral load of high-risk human papillomavirus that established infection in the reproductive tracts of women.Methods The secretions of cervical os and canal of 3 567 women, aged from 18 to 69,who participated in the cross-sectional survey,and who were married or were single but had already had sexual life,were collected and tested by HPV DNA testing,using the HCⅡtest.Patients who were found positive for high-risk HPV all had colposcopic biopsy,and in the follow-up,cytological and histological confirmation of their disease,in order that the application value of the method of HPV DNA testing could be identified.Results Of the 3 567 tested specimens,88 were found to be infected with high-risk HPV,among which,34(39%)were proved normal and 54(61%)abnormal by colposcopic biopsy.Conclusion The method of DNA test of high-risk types of HPV was proved to be effective in screening cervical viruses.It was also found that there was a positive correlation between the lesion status and the viral load of HPV.