摘要
目的研究太原汉族人群中载脂蛋白A5(ApoA5)-1131T/C基因多态性与冠心病(CHD)的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测了249例CHD患者和176例健康人群的ApoA5-1131T/C的多态性基因型和等位基因的分布。结果两组间ApoA5-1131T/C等位基因和基因型频率存在明显差异,等位基因C的频率在CHD组显著低于对照组(37.1%VS42.0%,P<0.05)。结论 ApoA5的基因多态1131T/C与CHD的发病率有一定的相关性(P<0.05)。
Objective To explore the relationship between gene pdymorphisms of apolipoprotein A5(ApoA5)-1131T/C and coronary artery disease(CHD)in Taiyuan Han population.Methods Polymerase chain reaction restricted fragments length polymophism(PCR-RFLP)was used to detect the polymorphism of ApoA5-1131T/C genotypes in 249 cases of CHD and 176 health people.Results The frequency of the ApoA5-1131 T/C allele and gene type was significantly different between the two group,especially with CC type dicreased in CHD compared with normal people(37.1% VS 42.0%,P<0.05).Conclusion The gene polymorphisms of ApoA5-1131T/C may be associated with the occurrence of CHD.
出处
《中国疗养医学》
2011年第6期487-489,共3页
Chinese Journal of Convalescent Medicine
关键词
载脂蛋白A5
冠心病
基因多态性
Apolipoprotein A5
Coronary heart disease
Gene polymorphisms
