寻常性银屑病患者血清内脂素和高迁移率蛋白-1的含量变化

Clinical significance of serum visfatin and high mobility groupbox-1(HMGB1) in patients with psoriasis vulgaris

目的探讨血清内脂素和高迁移率蛋白-1(HMGB1)含量变化在寻常性银屑病发病中的作用及其临床意义。方法应用双抗体夹心酶联免疫吸附法(ELISA)检测78例寻常性银屑病患者外周血清中内脂素和HMGB1的水平;并动态观察治疗前后内脂素和HMGB1的变化,及其与寻常性银屑病患者病情活动指标之间的关系。结果寻常性银屑病患者治疗前血清中内脂素和HMGB1的水平较健康对照组显著增高(t值分别为10.53和11.24,P均<0.01),且内脂素和HMGB1的水平与寻常性银屑病的分期有关,其中进行期患者组显著高于静止期患者组(t值分别为12.47和13.62,P均<0.01);治疗后血清中内脂素和HMGB1较治疗前显著下降(t值分别为12.72和11.48,P均<0.01)。内脂素的血清浓度变化与HMGB1水平及银屑病严重程度指数PASI评分呈正相关(r值分别为0.58和0.67,P均<0.01)。结论内脂素和HMGB1在寻常性银屑病的发病中可能起重要作用,血清内脂素和HMGB1的检测可作为反映寻常性银屑病病情活动的指标之一。

Objective To investigate the role and clinical significance of serum levels of visfatin and high mobility groupbox-1(HMGB1) in patients with psoriasis vulgaris.Methods Serum levels of visfatin and HMGB1 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 78 patients with psoriasis vulgaris.Results The serum levels of visfatin and HMGB1 were significantly higher than those after treatment and in normal controls (P<0.01),and there were significant difference between the active stage and the rest stage of psoriasis vulgaris (t=12.47,13.62,P<0.01).The serum levels of visfatin were associated with HMGB1 and PASI scores(r=0.58,0.67,P<0.01).Conclusions The visfatin and HMGB1 may be very important to the pathogenesis of psoriasis vulgaris.