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miR-210在胃癌组织中的表达及临床意义 被引量:5

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摘要 目的探讨miR-210在胃癌患者组织中的表达及其临床意义。方法采用实时定量PCR检测miR-210在60例胃癌患者组织中的表达情况。并应用统计学分析其与临床病理特点的相关性。结果胃癌组织中miR-210的表达明显高于对应的癌旁正常组织(P=0.019)。并且miR-210的表达与患者的年龄、性别、病灶位置、大体类型、分化程度无关,但与肿瘤的大小(P=0.012)、浸润深度(P=0.022)、淋巴结转移个数(P=0.032)、淋巴结是否转移(P=0.030)、是否有淋巴管癌栓(P=0.026)、是否发生远隔转移(P=0.016)、TNM分期(P=0.018)密切相关。结论 miR-210可能在胃癌的发生发展中发挥重要作用,并可能成为胃癌诊断的标志物和治疗的靶点。
出处 《中华临床医师杂志(电子版)》 CAS 2011年第9期2701-2703,共3页 Chinese Journal of Clinicians(Electronic Edition)
基金 国家自然科学基金(30873043 项目名称:PAK1调节miRNA-100对胃癌侵袭和转移的影响及机制研究)
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参考文献8

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共引文献10

同被引文献72

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