期刊文献+

Livin、缺氧诱导因子-1α在结肠癌中的表达及意义 被引量:8

原文传递
导出
摘要 目的探讨Livin、缺氧诱导因子-1α(HIF-1α)在结肠癌组织中的表达及意义。方法应用免疫组织化学染色法检测Livin、HIF-1α蛋白在30例正常结直肠黏膜,30例结直肠腺瘤,30例结直肠癌中的表达。结果结肠癌组织中Livin、HIF-1α阳性率明显高于结肠腺瘤和结肠正常黏膜组织(P<0.05)。结肠腺瘤和结肠正常黏膜组织Livin、HIF-1α阳性率无统计学差异(P>0.05)。结论 Livin、HIF-1α在结肠癌的发生及发展中起着重要作用。
出处 《中华临床医师杂志(电子版)》 CAS 2011年第10期3005-3007,共3页 Chinese Journal of Clinicians(Electronic Edition)
  • 相关文献

参考文献12

  • 1秦光远,黄桂林,邵建强,郭清江.大肠癌的治疗进展[J].医学综述,2009,15(1):58-60. 被引量:11
  • 2邓鑫,赵毅,马瑀,崔钊.PTEN、Smac和LIVIN在胃癌组织中的表达及其临床意义[J].山东医药,2008,48(32):25-27. 被引量:7
  • 3Irena Crnkovi?-Mertens,Julia Semzow,Felix Hoppe-Seyler,Karin Butz.Isoform-specific silencing of the Livin gene by RNA interference defines Livin β as key mediator of apoptosis inhibition in HeLa cells[J]. Journal of Molecular Medicine . 2006 (3)
  • 4Ferlay J,Bray F,Pisani P,et al.cancer incidence,mortality and prevalence worldwide. IARC Cancer Base . 2001
  • 5Lju B,Hart M.Livin/ML-IAP as a new target for cancer treatment. Cancer Letters . 2007
  • 6Vaupei P.The role of hypoxiainduced factors in tumor progression. Oncologiat . 2004
  • 7Hariu H,Hirohashi Y,Torigoe T,et al.Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer. Clinical Cancer Research . 2005
  • 8Kasof GM,Gomes BC.Livin, a novel inhibitor of apoptosis protein family member. Journal of Biological Chemistry . 2001
  • 9Gazzaniga P,Gradilone A,Giuliani L,et al.Expression and prognostic significance of livin,survivin and other apoptosis related genes in the progression of superficial bladder cancer. Annals of Oncology . 2003
  • 10Sun X,Kanwar JR,Leung E,et al.Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy. Gene Therapy . 2001

二级参考文献25

  • 1彭晓辉.大肠癌手术治疗进展[J].职业与健康,2005,21(11):1692-1695. 被引量:5
  • 2何友兼,董秋美,李宇红.结肠癌全身辅助化疗的进展[J].癌症,2005,24(12):1546-1549. 被引量:13
  • 3吴洪波,于雁.大肠癌基因治疗进展[J].国际肿瘤学杂志,2006,33(5):376-379. 被引量:4
  • 4张力,王志强.大肠癌靶向治疗进展[J].中国癌症杂志,2007,17(1):18-23. 被引量:19
  • 5吴智群,王执民.肿瘤介入治疗的现状与展望[J].介入放射学杂志,2007,16(6):361-362. 被引量:4
  • 6Ferlay J, Bray F, Pisani P, et al. GLOBOCAN 2000: cancer incidence, mortality and prevalence worldwide [ R ]. Version 1.0. IARC Cancer Base No. 5, Lyon : IARC 2001.
  • 7Heald RJ,Husband EM, Ryall RD. The mesorectum in recall cancer surgery-the clue to pelvic recurrence [ J ]. Br J Surg, 1982,69 (10) :613-616.
  • 8Heald R J, Karanjia ND. Resuhs of radical surgery for rectal cancer [J]. World J Surg,1992,16(5) :848-857.
  • 9Tilney HS,Lovegrove RE, Purkayastha S, et al. Comparison of colonic stenting and open surgery for malignant large bowel obstruction[J]. Surg Endosc,2007,21 (2) :225-233.
  • 10Mazhar D,Stebbing J, Heller W. Recent advances in the systemic management of colorectal cancer[J]. Future Oncol, 2006,2 ( 5 ) : 643 -650.

共引文献16

同被引文献39

引证文献8

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部