乳腺导管内癌临床特点与外科治疗方式的研究

Research on the clinical characteristics and surgical treatment of ductal carcinoma in situ

目的探讨乳腺导管内癌(DCIS)临床特点与外科治疗方式的选择。方法回顾性分析我院2001年1月至2010年12月57例DCIS患者,总结其临床特点、病理特征与外科手术方式等,术后随访有无局部复发或远处转移等情况,探讨该病临床特点、如何选择恰当的外科治疗方式。结果在相同术后辅助治疗的前提下,保乳手术与传统的乳腺癌改良根治术对患者的术后预后情况影响差异无统计学意义(P>0.05);在相同手术方式前提下,综合治疗方案可明显改善患者预后(P<0.05)。结论 DCIS综合治疗效果确切,明显优于单纯手术治疗,可显著减少术后局部复发或远处转移;保乳手术在保留乳腺外形、增强患者自信心等优点基础上还可获得与传统乳腺癌改良根治术相同的预后效果。

Objective To explore the clinical characteristics and surgical treatment options of ductal carcinoma in situ.Methods We retrospectively analysed 57 intraductal carcinoma patients from January 2001 to December 2010,summarizing its clinical characteristics,pathological characteristics and surgical methods etc,following-up local recurrence or distant metastasis,discussing the clinical characteristics and choosing appropriate surgical interventions.Results In the same postoperative adjuvant treatments,breast-conserving surgery and traditional modified radical mastectomy for improving prognosis had no statistically significant difference(P>0.05).In the same operation method premise,comprehensive treatment can significantly improve the prognosis of patients(P<0.05).Conclusions The effect of comprehensive treatments of ductal carcinoma in situ is obviously better than simple surgery,markedly reducing postoperative local recurrence and distant metastasis;breast-conserving operation,which could retain breast appearance and enhance patients,confidence,can obtain the same outcome effect as traditional modified radical mastectomy.