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游离脂肪酸做好作为常规临床检测的准备了吗 被引量:2

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摘要 1963年,Randel等提出了"葡萄糖-脂肪酸循环"学说,认为葡萄糖和脂肪酸的氧化代谢存在相互竞争,提示脂肪酸在代谢中存在重要作用。近来的研究发现,血浆游离脂肪酸(free fatty acid,FFA)浓度的升高与糖尿病、动脉硬化以及多种代谢疾病均有密切的关系[1],因此在各种代谢疾病中进行FFA的研究已经成为内分泌代谢领域的一个热点。
出处 《中华临床医师杂志(电子版)》 CAS 2011年第13期3709-3711,共3页 Chinese Journal of Clinicians(Electronic Edition)
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  • 1Menéndez LG,Fernández AL,Enguix A,et al.Effect of storage of plasma and serum on enzymatic determination of non-esterified fatty acids[].Annals of Clinical Biochemistry.2001
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同被引文献29

  • 1刘长锁,申竹芳.游离脂肪酸与胰岛素抵抗[J].中国药理学通报,2005,21(2):145-149. 被引量:37
  • 2Xu N, Dahlbck B. A novel human apolipoprotein (ApoM)[J]. J Biol Chem, 1999,274:31286-31290.
  • 3Zhang X, Jiang B, Luo G, et al. Hyperglycemia down-regulates Apolipoprotein M expression in vivo and in vitro[J]. Biochim Biophys Acta, 2007,1771:879-882.
  • 4Reaven GM. The Fourth Musketeer——from Alexandre Dumas to Claude Bernard[J]. Diabetologia, 1995,38:3-13.
  • 5Schalch DS, Kipnis DM. Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids[J]. J Clin Invest, 1965,44:2010-2020.
  • 6Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role[J]. Best Pract Res Clin Endocrinol Metab, 2005,19:471-482.
  • 7Nunome Y, Tsuda T, Kitagawa K. Determination of fatty acids in human sweat during fasting using Gc/Ms[J]. Anal Sci, 2010,26:917-919.
  • 8Wolfrum C, Poy MN, Stoffel M. Apolipoprotein M is required for Prebeta-Hdl formation and cholesterol efflux to Hdl and protects against atherosclerosis[J]. Nat Med, 2005,11:418-422.
  • 9Mulya A, Seo J, Brown AL, et al. Apolipoprotein M expression increases the size of nascent pre beta Hdl formed by ATP Binding cassette transporter A1[J]. J Lipid Res, 2010,51:514-524.
  • 10Xu N, Ahren B, Jiang J, et al. Down-regulation of Apolipoprotein M expression is mediated by phosphatidylinositol 3-kinase in HepG2 cells[J]. Biochim Biophys Acta, 2006,1761:256-260.

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