住院焦虑障碍患者的脑电超慢涨落图分析

Analysis of encephalofluctuogram technology in in-patients with anxiety disorder

目的用脑电超慢涨落图分析仪(ET)在无创条件下观察焦虑障碍患者脑内神经递质活动情况。方法在焦虑障碍患者入院当天用ET提取在脑电中载有脑神经递质调节系统的震荡信息(即S谱线),分析焦虑障碍患者脑神经递质的活动情况,同时用汉密尔顿焦虑量表(HAMA)评定其临床症状。结果 (1)与期望值对照:γ-氨基丁酸(GABA)(4.79±4.09vs.8.15±0.53,P<0.001)活动降低;乙酰胆碱(Ach)(17.49±5.54vs.15.18±1.01,P=0.002)、乙酰胆碱受体(AchR)(32.69±9.58vs.28.82±1.67,P=0.002)、五羟色胺(5-HT)(22.67±5.98vs.19.99±0.71,P<0.001)、去甲肾上腺素(NE)(13.03±4.33vs.10.82±0.83,P=0.002)、谷氨酸(Glu)(7.69±3.19vs.5.05±1.02,P<0.001)活动增高。(2)HAMA精神性焦虑因子中紧张的评分与5-HT(r=0.308,P<0.05)、Ach(r=0.322,P<0.01)、AchR(r=0.262,P<0.05)活动呈正相关;焦虑心境的评分与Ach活动呈正相关(r=0.293,P<0.05)、与AchR活动呈负相关(r=-0.278,P<0.05);躯体性焦虑因子中,心血管系统症状的评分与GABA活动呈负相关(r=-0.288,P<0.05),与Glu活动成正相关(r=0.273,P<0.05);自主神经系统症状与NE活动成正相关(r=0.242,P<0.05),与Ach活动成正相关(r=0.293,P<0.05)。结论焦虑障碍患者脑内神经递质NE、5-HT、GABA、Ach、Glu活动发生异常,可能参与了焦虑障碍症状的产生。

Objective To investigate the change characteristics of the brain neurotransmitters of patients with anxiety disorder by employing the encephalofluctuograph(ET) on the noninvasive condition.Methods Shocking informations with neurotransmitter requlation systems in EEG(s spectral line) were extracted by employing the ET in a hospital's same-day and the change characteristics of the brain neurotransmitters of in-patients with anxiety disorder were analyzed.The clinical symptoms of the patients were evaluated by the Hamilton anxiety scale(HAMA).Results(1)Compared with the expected number:the activity of neurotransmitters such as γ-aminobutyric acid(GABA)(4.79±4.09 vs.8.15±0.53,P<0.001)was significantly decreased,and the activity of neurotransmitters such as acetylcholine(Ach)(17.49±5.54 vs.15.18±1.01,P=0.002),Ach receptors(32.69±9.58 vs.28.82±1.67,P=0.002),serotonin(5-HT)(22.67±5.98 vs.19.99±0.71,P<0.001),glutamic acid(Glu)(7.69±3.19 vs.5.05±1.02,P<0.001),norepinephrine(NE)(13.03±4.33 vs.10.82±0.83,P=0.002)were higher.(2)In mental anxiety factors,tension factor had a positive correlation to the activity of 5-HT(r=0.308,P<0.05),Ach(r=0.322,P<0.01)and AchR(r=0.262,P<0.05);anxious mood factor had a positive correlation to the activity of Ach(r=0.293,P<0.05),and has a negative correlation to the activity of AchR(r=-0.278,P<0.05);in somatic anxiety factors,the cardiovascular system symptoms were negative correlated with the activity of GABA(r=-0.288,P<0.05),and were positive correlated with the activity of Glu(r= 0.273,P<0.05);autonomic nervous symptoms were positive correlated with the activity of NE(r=0.242,P<0.05)and Ach(r=0.293,P<0.05).Conclusions NE,5-HT,GABA,Ach,Glu neurotransmitters are significantly changed in anxiety disorder in-patients,and maybe participate in the anxiety occurs.