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二甲双胍对肿瘤抑制作用的研究进展 被引量:5

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摘要 大量研究证实,糖尿病患者与某些癌症的罹患率之间存在相关关系,而且相比较没有糖尿病的癌症患者,糖尿病合并癌症的患者对化疗药物的敏感性降低、具有更多并发症、预后更差[1]。二甲双胍(metformin)是美国糖尿病学会(American diabetes association,ADA)在欧洲糖尿病研究协会(European Association for the Study of Diabetes,EASD)
作者 李章芳 沈洁
出处 《中华临床医师杂志(电子版)》 CAS 2011年第17期5081-5083,共3页 Chinese Journal of Clinicians(Electronic Edition)
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  • 1Valter Donadon,Massimiliano Balbi,Francesca Valent,Angelo Avogaro.Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma[J].World Journal of Gastroenterology,2010,16(24):3025-3032. 被引量:15
  • 2王祎波,王瑜,王烈.降糖药二甲双胍抗肿瘤的作用机制[J].医学综述,2010,16(4):610-612. 被引量:6
  • 3Emily Jane Gallagher,Derek LeRoith.Insulin, Insulin Resistance, Obesity, and Cancer[J]. Current Diabetes Reports . 2010 (2)
  • 4R. Han,R. Lai,Q. Ding,Z. Wang,X. Luo,Y. Zhang,G. Cui,J. He,W. Liu,Y. Chen.Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism[J]. Diabetologia . 2007 (9)
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  • 6Simpson SH. 69th Scientific Sessions . 2009
  • 7Li D,Yeung SC,Hassan MM,et al.Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology . 2009
  • 8Hirsch HA,,Iliopoulos D,Tsichlis PN,et al.Metformin selectively targets cancer stem cells,and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Research . 2009
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  • 10Woodard J,Platanias LC,Robert H.AMP-activated kinase(AMPK)-generated signals in malignant melanoma cell growth and survival. Biochemical and Biophysical Research Communications . 2010

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