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生长分化因子-15基因多态性的研究进展 被引量：3

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摘要 生长分化因子-15(GDF-15)的基因定位于染色体19p12-13.1,由两个外显子组成,被一个长约1800个碱基对的内含子分隔开来[1]。外显子Ⅰ由309个碱基对组成,其5'-端非翻译区有71个碱基对。外显子Ⅱ由647个碱基对组成,其3'-端的非翻译区有244个碱基对。GDF-15基因的启动子区域包含两个p53和Egr1的结合位点,这是两种在GDF-15诱导表达过程中起关键作用的转录蛋白[2-4],也是与心血管疾病密切相关的转录调节蛋白[5-6]。
作者 花苏榕 张抒扬
机构地区 中国医学科学院北京协和医学院 中国医学科学院北京协和医学院北京协和医院心内科
出处 《中华临床医师杂志（电子版）》 CAS 2011年第22期6688-6690,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 GDF 高血压患者 研究结果 血浆水平 心室肥厚 相关性 基因多态性 遗传多态性 分化因子 前列腺癌 携带者
分类号 R346 [医药卫生—基础医学]
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参考文献24

  • 1Daniel Schlittenhardt,Andreas Schober,Jens Strelau,Gabriel A. Bonaterra,Walther Schmiedt,Klaus Unsicker,Jürgen Metz,Ralf Kinscherf.Involvement of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in oxLDL-induced apoptosis of human macrophages in vitro and in arteriosclerotic lesions[J]. Cell and Tissue Research . 2004 (2)
  • 2Tan M,Wang Y,Guan K,et al.PTGF-beta,a type beta transforming growth factor(TGF-beta)superfamily member,is a p53target gene that in-hibits tumor cell growth via TGF-beta signaling pathway. Proceedings of the National Academy of Sciences of the United States of America . 2000
  • 3Kempf T,Eden M,Strelau J,et al.The transforming growth factor-beta superfamily member growth-differentiation factor-15protects the heart from ischemia/reperfusion injury. Circulation Research . 2006
  • 4Brown DA,Bauskin AR,Fairlie WD,et al.Antibody-based approach to high-volume genotyping for MIC-1polymorphism. Biotechniques . 2002
  • 5Wang X,Yang X,Sun K,et al.The haplotype of the growth-differentiation factor15gene is associated with left ventricular hypertrophy in human essential hypertension. Clinical Science Lond . 2010
  • 6Hayes VM,Severi G,Southey MC,et al.Macrophage inhibitory cytokine-1H6D polymorphism,prostate cancer risk,and survival. Cancer Epidemiology Biomarkers and Prevention . 2006
  • 7Chen Z,Xie F,Ma G,et al.Study of the association between growth differentiation factor15gene polymorphism and coronary artery disease in a Chinese population. Molecular Biology Reports . 2011
  • 8Li P X,Wong J,Ayed A,et al.Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53overexpression. Journal of Biological Chemistry . 2000
  • 9Mercer J,Bennett M.The role of p53 in atherosclerosis. Cell Cycle . 2006
  • 10Khan SQ,Ng K,Dhillon O,et al.Growth differentiation factor-15as a prognostic marker in patients with acute myocardial infarction. European Heart Journal . 2009

同被引文献40

  • 1Ago T, Sadoshina J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res, 2006, 98: 294-297.
  • 2TobinJF, Celeste AJ. Bonemorphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease. Drug Discov Today, 2006, 11: 405-411.
  • 3Bauskin AR, Brown DA, Kuffner T, et al. Role of macrophage inhibitory cytokine-1 in tumo- rigenesis and diagnosis of cancer . Cancer Res, 2006, 66: 4983-4986.
  • 4Kempf T, Sinning JM, Quint A, et al. Growth- differentiation factor-15 for risk stratification in patients with stable and unstable coronary heart disease: results from the AtheroGene study. Circ Cardiovasc Genet,2009,2 :286-292.
  • 5Bottner M, Suter-Crazzolara C, Schober A, et al. Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/ macrophage- inhibiting eytokine-l(GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res, 1999,297 : 103-110.
  • 6Wollert KC. Growth-differentiation factor-15 in cardiovascular disease: from bench to bedside, and back . Basic Res Cardiol, 2007, 102:412-415.
  • 7Kempf T, Horn-Wichmann R, Brabant G, et, al. Circulating concentrations of growthdifferentiation factor-15 in,apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay. Clin Chem, 2007,53 : 284-291.
  • 8Kempf T, Eden M, Strelau J, et al. The transforming growth factor-beta superfamily member growth differentiation factor-15 protects the heart from ischemia/ reperfusion injury. Circ Res, 2006, 98: 351-360.
  • 9Mercer J, Bennett M. The role of p53 in atherosclerosis. Cell Cycle, 2006,5 : 1907-1909.
  • 10Xu J, Kimball TR, Lorenz JN, et al GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res, 2006, 98: 342- 350.

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中华临床医师杂志（电子版）
2011年 第22期

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