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Klotho基因及其与心血管疾病关系研究进展 被引量:2

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摘要 Klotho基因是一种与人类衰老密切相关的新基因,其主要在肾脏和脑脉络膜中表达,其分泌性蛋白是一种与衰老有关的激素,为此推测该基因表达可能对衰老相关性疾病(如老年高血压、冠心病、动脉硬化等)的发生发展起作用。
出处 《中华临床医师杂志(电子版)》 CAS 2011年第23期7000-7001,共2页 Chinese Journal of Clinicians(Electronic Edition)
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参考文献17

  • 1刘晓林,马厚勋,田小春,吴平,周平,李法琦.Klotho基因3个SNP位点与老年高血压及脂代谢的相关性[J].中国老年学杂志,2010,30(23):3429-3432. 被引量:15
  • 2华明娟,马厚勋,牛永红,谢正祥.KLOTHO的3个SNP位点分布与几种疾病相关性的研究[J].中国现代医学杂志,2008,18(9):1174-1178. 被引量:15
  • 3王虎林,司良毅,孙兰英,孟萍,肖航.Klotho基因G-395A多态性与动脉硬化的相关性研究[J].中华老年心脑血管病杂志,2008,10(2):96-98. 被引量:15
  • 4Liu H,Fergusson MM,Castilho RM,et al.Augmented Wnt signaling in a mammalian model of accelerated aging. Science . 2007
  • 5Kuro-o M.Klotho and aging. Biochimica et Biophysica Acta . 2009
  • 6Chen CD,Podvin S,Gillespie E,et al.Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10and AD-AM17. Proceedings of the National Academy of Sciences of the United States of America . 2007
  • 7Bloch L,Sineshchekova O,Reichenbach D,et al.Klotho is a substrate for alpha-,beta-and gamma-secretase. FEBS Letters . 2009
  • 8Wang YH,Sun ZJ.Klotho gene de-livery prevents the progression of spontaneous hypertension and renal damage. Journal of Hypertension . 2009
  • 9Rhee EJ,Oh KW,Yun EJ, et al.Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the klotho gene with glucose metabolism and cardiovascular risk factors in Korean women. Journal of Endocrinological Investigation . 2006
  • 10Arking DE,Atzmon G,Arking A,et al.Association between a functional variant of the klotho gene and high-density lipoprotein cholesterol,blood pressure,stroke,and longevity. Circulation Research . 2005

二级参考文献22

  • 1李志祥,谢桂岚.MN血型M基因单核苷酸多态性在中国北京汉族人群中分布状态的初步调查[J].中国现代医学杂志,2005,15(2):224-226. 被引量:4
  • 2LIU Dong-hong,WANG Yan,LIAO Xin-xue,XU Ming-guo,WANG Jie-mei,YANG Zhen,CHEN Long,LU Ming-de,LU Kun,TAO Jun.Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease[J].Chinese Medical Journal,2006(22):1866-1870. 被引量:17
  • 3王虎林,肖航,司良毅.Klotho基因与心血管病的关系及研究现状[J].中华老年心脑血管病杂志,2007,9(2):136-138. 被引量:3
  • 4Xiao N,Zhang Y,Zheng Q,et al.Klotho is a serum factor related to human aging[J].Chin Med J,2004;117(5):742-7.
  • 5Burt VL,Whelton P,Roccella EJ,et al.Prevalence of hypertension in the US adult population.Results from the Third National Health and Nutrition Examination Survey1988-1991[J].Hypertension,1995;25(3):305-13.
  • 6Ong KL,Cheung BM,Man YB,et al.Prevalence,awareness,treatment,and control of hypertension among United States adults 1999-2004[J].Hypertension,2007;49(1):69-75.
  • 7Takeshita K,Fujimori T,Kurotaki Y,et al.Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression[J].Circulation,2004;109(14):1776-82.
  • 8Arking DE,Atzmon G,Arking A,et al.Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol,blood pressure,stroke,and longevity[J].Circ Res,2005;96(4):412-8.
  • 9Kawano K,Ogata N,Chiano M,et al.Klotho gene polymorphisms associated with bone density of aged postmenopausal women[J].J Bone Miner Res,2002;17(10):1744-51.
  • 10Shimoyama Y,Taki K,Mitsuda Y,et al.KLOTHO gene polymorphisms G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric acid in Japanese hemodialysis patients[J].Am J Nephrol,2009;30(4):383-8.

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