α_1受体激动剂联合盐酸黄酮哌酯治疗前列腺术后尿失禁

Combined treatment for incontinence resulting from prostatectomy

目的:评价α_1受体激动剂联合盐酸黄酮哌酯治疗前列腺术后尿失禁的疗效。方法:前列腺术后(TURP)尿失禁患者23例,症状评分(ICI-Q-SF)4～18分,即10.48±3.55分;口服二联药物,即α_1受体激动剂(盐酸米多君),2～3/d,每次2.5～5mg,及盐酸黄酮哌酯,2～3/d,每次0.4。结果:23例均在治疗后2d 症状明显缓解或消失。4周后停药,20例症状评分降为0分,3例评分为3～8分,继续治疗至第12周后停药,2例症状评分为降为0分,1例降至5分。结论:α_1受体激动剂(盐酸米多君)联合盐酸黄酮哌酯能有效控制前列腺术后尿失禁症状,恢复尿控,改善恢复期生活质量,治疗安全、简便。

Objective:To evaluate the clinical efficacy of Midodrine Hydrochloride combined with Flavoxate Hydrochloride for incontinence resulting from prostatectomy.Methods:23 patients of incontinence with Symptom Score (ICI-Q-SF) 4-18 resulting from prostatetomy were treated with Midodrine Hydrochloride (2.5mg or 5mg bid or tid) combined with Flavoxate Hydrochloride (0.4 bid or tid).Results:Symptoms of all patients were obvi- ously improved after two days of treatment.In 20 of them symptoms disappeared at the end of 4 weeks,and in 2 of them incontinence disappeared after 12 weeks.Only in one case,the ICI-Q-SF remained to be 5 after treatment. No side-effect was found in these cases.Conclusions:Midodrine Hydrochloride combined with Flavoxate Hydro- chloride could significantly improve the symptom of incontinence resulting from prostatectomy.It appears to be a safe and simple method.