抗生素与H_2受体拮抗剂联用对外科手术患者全身炎症反应综合征发病率和预后的影响

Effects of combined use of antibiotic and H_2-antagonists on incidence of system inflamation response syndrome(SIRS)and prognosis in surgical patients

目的:探讨外科手术后联合应用抗生素及 H_2受体拮抗剂对患者 SIRS 发病率及预后的影响。方法:回顾性地对4年半余本院外科手术后患者未用、单纯应用和伍用抗生素和/或 H_2受体拮抗剂后的 SIRS 发病率及预后进行临床分析。结果:单纯应用抗生素或 H_2受体拮抗剂的患者 SIRS 发病率较未用组患者明显降低;抗生素和 H_2受体拮抗剂联用的患者较未用组和单纯应用组 SIRS 发病率显著降低;单纯应用抗生素或 H_2受体拮抗剂组间比较 SIRS 发病率无显著差异;各组 SIRS 发生后病死率无显著差异。结论:外科手术后患者联合应用抗生素和 H_2受体拮抗剂可以明显减少 SIRS 的发病率,但对 SIRS 发生后患者的病死率影响较小。

Objective:To investigate the effects of combined administration of antibiotic and H_2-antagonists on incidence of SIRS and prognosis in surgical patients.Methods:We retrospectively analyzed the incidence of SIRS and prognosis in patients who received either antibiotic alone or together with H_2-antagonists after surgery in our hospital during past four and half years.Results:The incidence of SIRS in patients treated with either antibiotic or H_2-antagonists was significantly decreased compared with those who were not treated.Patients with combined treatment of antibiotic and H_2-antagonists resulted in a significant decrease in the incidence of SIRS in comparison with other groups.There was no significant difference in the incidence of SIRS between antibiotic group and H_2- antagonists group.There was also no significant difference in prognosis in all groups when SIRS occurred.Conclu- sion:Combined treatment of antibiotic and H_2-antagonists in patients after surgery could decrease the incidence of SIRS,but did not make difference in the mortality.