头孢吡肟治疗产超广谱β-内酰胺酶菌株感染探讨

Antibacterial effect of cefepime on infection of the extended spectrumβ-lactamase producing bacteria

目的：探讨头孢毗肟对产超广谱β-内酰胺酶菌感染的治疗结局。方法：观察112株产超广谱酶(ES- BL)菌株,比较体外和体内对三代和四代头孢菌素敏感率和治疗治疗结果；结果：1)ESBL菌株在送检标体中的检出比率呈上升趋势；2)ESBL菌株对四代头孢体外敏感率与三代头孢相比较P＜0．01有显著差异；但体内疗效比较却无差异P＞0．05。结论：ESBL菌株对四代头孢体外敏感率与三代头孢相比较,其敏感率有显著差异,但体内疗效却无差异,头孢吡肟对ESBL菌株治疗无效；临床科、检验科、药剂科应重视ESBL的感染。

Objective:To assess the antibacterial effect of eefepime on infection of the extended spectrumβ-lacta- mase(ESBL)producing bacteria.Methods:The sensitive rate in vitro,antimicrobial susceptibility test and the treatment outcome in vivo of cephalothin were compared with those of cefepime against 120 strains of E.coli and 44 strains of Klebsiella spp with ESBL.Results:1)The rate of isolation of bacterium with ESBL was found to be increased,and significant difference in sensitive rate in vitro(P＜0.01)was found between the third generation and the fourth generation cephalothin,though there was no marked difference in vivo (P＞0.05).Conclusions: There appears to be no marked difference in antibacterial effect on ESBL in vivo between these two generation of antibiotics.More attention should be paid to the infection with ESBL producing bacteria in clinical settings,