烧伤病区抗感染药物使用的回顾性研究

Retrospective study on antibiotic use in a burn unit

目的:对我院烧伤病区5年来抗感染药物的使用情况进行分析,为临床合理使用抗感染药物提供依据。方法:采用约定每日剂量(DDD)对常用抗感染药物用量进行精确量化,结合主要病原菌耐药水平的变化,对抗感染药物使用的合理性以及与病原菌耐药水平的关系病原菌耐药水平的关系进行研究。结果:我院烧伤病区5年来抗感染药物使用总量和经费消耗均稳中有降,而且病原菌对多数一线抗感染药物的耐药率也有一定幅度的下降。使用频率最高的抗感染药物是低价位的一线药物,一些病原菌对长期使用频率较高抗感染药物的耐药水平没有明显增高。结论:我院烧伤病区在抗感染药物总量控制和抗感染药物合理使用方面的措施发挥了积极作用;改变抗感染药物使用策略有可能降低病原菌的耐药水平。

Objective: To analyze the antibiotic use in the burn unit of our hospital from 1995～1999. Methods: The defined daily doses (DDD) was used to evaluate the antibiotic consumption. The relationship between antibiotic consumption and rate of pathogen resistance were investigated. Results: The total antibiotic consumption and its expenses were decreased, and the resistance rate of pathogen to frequently used antibiotics were declined in burn unit during the past five years. Conclusion: The measures to control antibiotic total consumption and to promote judicious antibiotic use may play beneficial effects in burn unit. Optimization of antibiotic strategy would be a potentially possible way to reduce the resistant rate of pathogens.