PCNA在增生性瘢痕和慢性溃疡中的表达特征及其意义

The Significance of changes in PCNA expression in hypertrophic scars and chronic ulcers

目的:研究PCNA在增生性瘢痕和慢性溃疡中的表达特征,探讨其与增生性瘢痕和慢性溃疡发生的关系。方法:采用免疫组织化学SP方法检测组织中的PCNA表达量及其定位。结果:在所测定的8例增生性瘢痕和8例慢性溃疡标本中均有PCNA阳性表达,PCNA在增生性瘢痕中的表达量明显高于慢性溃疡组织(P<0.01)。两种组织中PCNA表达定位于成纤维细胞和毛细血管内皮细胞的胞核内。结论:PCNA在增生性瘢痕中的表达量较高,而在慢性溃疡中的表达量较低,PCNA的不同表达量可能与增生性瘢痕和慢性溃疡的形成有关。

Objective:To investigate the characteristics of PCNA expression in hypertrophic scars and chronic ulcers and its relation to the development of scar and ulcer formation. Methods:The expressive quantity and sites of PCNA were determined by using immunohistochemical SP method. Results:PCNA were expressed in all samples from 8 hypertrophic scars and 8 chronic ulcers. The expressive levels in hypertrophic scars were higher than that in chronic ulcers (P<0.01). The expressive sites were in the nuclei in fibroblasts and capillary endothelial cells. Conclusion:The expressive levels of PCNA were higher in hypertrophic scars than in chronic ulcers. The difference between hypertrophic scars and chronic ulcers may be related with the development of scar and ulcer formation.