摘要
采用Pd/C作催化剂,无水甲醇作溶剂,研究了超声波辐射下苯乙酮与甲酸铵反应制备α-苯乙胺的反应,考察了反应物摩尔比、反应温度、反应时间、Pd/C用量、辐射功率对反应的影响并优化了反应工艺。结果表明:在超声波辐射下,n(甲酸铵):n(苯乙酮)为2:1,m(10%Pd/C):m(苯乙酮)为1:10,V(水):V(甲醇)为1:9,常压40℃下反应30 min,α-苯乙胺的收率为80.2%,实验的重复性良好。Pd/C易分离回收,可重复使用5次以上。
α-Phenylethylamine was synthesized with ammoniumformate and acetophenone catalyzed by Pt/C using methylol as solvent under ultrasonic irridiation.The effect of the mole ratio of substitutes,reaction temperature,reaction time, the amount of Pd/C and ultrasonic power were investigated,and the reaction conditions were optimized.Results show that the title product is obtained with yield of 80.2%under ultrasonic irradiation at 40℃for 30 min when n(ammoniumformate): n(acetophenone) is 2:1,m(10%Pd/C):m(acetophenone) is 1:10,(H2O):(methylol) is 1:9.The Pd/C catalyst can be easy of recovery for reusing again over 5 times.
基金
湖南省教育厅计划资助项目(08C202)
关键词
Α-苯乙胺
超声波辐射
甲酸铵
苯乙酮
合成
α-phenylethylamine
ultrasonic irradiation
ammoniumformate
acetophenone
synthesis
