老年慢性精神分裂症和阿尔茨海默病的认知电位P_(300)比较

Comparison of cognitive potential P_(300) among patients with senile chronic schizophrenic and Alzheimer's disease

目的探讨老年慢性精神分裂症(SCS)和阿尔茨海默病(AD)患者的认知电位(CP)P300的特点。方法对38例SCS患者、32例AD患者及40例健康老人对照组(NC)进行P300检测。结果 SCS组、AD组和NC组在靶潜伏期(Oz脑区N2)、靶波幅(Oz脑区P3)、非靶波幅(Oz脑区P2)上均有显著差异(P<0.01)。AD组表现为主成分N2延迟,与NC组和SCS组有极显著差异(P<0.01)。SCS组和AD组的靶波幅P3和非靶波幅P2均见降低,与NC组比较有显著差异(P<0.05)。结论作为反映认知功能障碍的客观生理指标,P300有可能作为SCS和AD辅助诊断的一个脑电生理学标志。

Objective To investigate the characteristics of cognitive potential P300 in patients with senile chronic schizophrenics(SCS) and Alzheimer's disease(AD).Methods The auditory P300 were detected in 38 patients with SCS,32 patients with AD and 40 elderly healthy controls.Results There were significant differences in P300 latencies(Oz/N2) and amplitudes(Oz/P3,Oz/P2) between SCS,AD,and controls.The latency of principal component N2 was significantly prolonged in AD group than that in the SCS group or the controls(P<0.01).The SCS and AD group had decreased P3 and P2 amplitudes compared with the NC group(P<0.05).Conclusion As a objective physiological indicator of cognitive function,the P300 might be used as a physiological index in diagnosis of AD and SCS.