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香港实施DOT后(1986-1999)结核分支杆菌的耐药性监测 被引量:2

Surveillance of Mycobacterium tuberculosis drug resistance in Hong Kong, 1986-1999, after the implementation of directly observed treatment
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摘要 目的:了解香港1986-1999年间不同年龄组结核病流行病学,尤其是耐药率的变化趋势。 设计:在香港某结核病中心实验室连续收集了临床结核分支杆菌对链霉素(SM)、异烟肼(INH)、利福平(RMP),以及对乙胺丁醇(EMB)的药物敏感性检测数据。测量并分析了新发病例和复治病例中诸如年龄性别以及耐药率等流行病学参数的时间变化趋势。 结果:在分离于新发病例的48924株非复制分支杆菌中,7045株(14.4%)对一种或一种以上药物耐受,5773株(11.8%)对SM和/或INH耐药,881株(1.8%)为耐多药株(MDR-TB)。在分离于复治病例的3857株分支杆菌中,1176株(30.5%)对一种或一种以上的药物耐受,616株(16.0%)对SM和/或INH耐药,467株(12.1%)为耐多药株(MDR-TB)。在新发病例的分支杆菌中,总和耐药率、SM单耐药率、INH单耐药率、SM+INH耐药率以及INH+RMP耐药率均表现出明显下降趋势。对于复治病例的分支杆菌中,也观察到了总和耐药率和INH+RMP耐药率的明显下降趋势。无论是在新发病例还是在复治病例,与其他年龄组相比(16-34岁和35-65岁),65岁以上病人分支杆菌的耐药率(总和耐药率和INH+RMP耐药率)明显低于其他年龄组(16-34和35-65岁组)。 结论:经过14年成功实施DOTS策略,以实验室检测数据为基础的监测结果显示分支杆菌的耐药率包括MDR率?
出处 《国际结核病与肺部疾病杂志》 2002年第3期92-99,共8页 The International Journal of Tuberculosis and Lung Disease
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