E-cd/γ-cat复合体在膀胱癌中的表达及临床意义

E-cadherin/γ-catenin Complex Expression in Human Bladder Carcinoma and Its Clinical Significance

目的 探讨上皮钙黏蛋白 /γ -连接素 (E cd/γ cat)复合体在膀胱癌中的表达及临床意义。方法应用免疫组织化学法 (S P法 )检测 72例膀胱癌和 5例正常膀胱黏膜石蜡包埋标本中E cd/γ cat复合体的表达情况。结果 所有 5例正常膀胱黏膜E cd/γ cat复合体正常表达。E cd、γ cat异常表达率分别为 4 1/ 72 (5 6 .9% )、31/ 72 (4 3.1% )。E cd和γ cat表达具有显著相关性 (P <0 .0 1)。E cd/γ cat复合体异常表达率与膀胱癌的病理分级和临床分期密切相关 (P <0 .0 5 )。γ cat异常表达与膀胱癌的预后密切相关 (P <0 .0 1)。结论 E cd/γ cat复合体的异常表达与膀胱癌的分化和侵袭程度密切相关。γ

Objective To elucidate the expression of E cadherin/γ catenin(E cd/γ cat)complex and its clinical significance in human bladder carcinoma.Methods The immunohistochemical staining with streptavidin peroxidase conjugated method (S P) was used to examine the expression of E cd/γ cat complex in 72 cases of human bladder carcinoma and 5 cases of normal bladder mucosa.Results E cd/γ cat complex was expressed in a normal membranous pattern in all normal bladder mucosa specimens. The abnormal expression of E cd/γ cat was found in 41/72 ( 56.9% ), 31/72( 43.1% ) tumors, respectively. A highly significant correlation was observed between expression of E cd and γ cat ( P < 0.01 ). There was a significant correlation between the abnormal expression of E cd/γ cat complex and WHO grade and TNM stage ( P < 0.05 ). The abnormal expression of γ cat was correlated with poor survival of all tumors ( P < 0.01 ).Conclusion The abnormal expression of E cd/γ cat complex plays an important role in the differentiation and malignant progress of human bladder carcinoma.γ cat may be a valuable prognostic marker of survival.