VEGF-C、CXCR4在乳腺浸润性导管癌组织中的表达及意义

Expressions and significance of VEGF-C and CXCR4 in breast infiltrating ductal carcinoma

目的分析血管内皮生长因子-C(VEGF-C)、趋化因子受体-4(CXCR4)在乳腺浸润性导管癌组织及乳腺纤维腺瘤组织中的表达,探讨其与淋巴管生成、乳腺癌的淋巴转移的关系。方法应用免疫组织化学方法检测72例乳腺癌组织、15例乳腺纤维腺瘤中VEGF-C、CXCR4的表达。结果 72例乳腺癌组织中VEGF-C、CXCR4的表达率分别为76.4%、58.3%,显著高于乳腺纤维腺瘤组织(20%、13.3%),差异有统计学意义(P<0.01)。VEGF-C、CXCR4的表达与患者的年龄、肿瘤大小、雌孕激素受体(ER、PR)的表达无关(P>0.05),而与组织学分级、临床分期、淋巴管的浸润及淋巴结转移有关(P<0.01)。结论 VEGF-C、CXCR4在介导乳腺癌细胞淋巴管浸润及淋巴结转移中可能起重要协同作用。

Objective To investigate the expressions of vascular endothelial growth factor-C(VEGF-C) and chemokines receptor-4(CXCR4) in breast infiltrating carcinoma and breast fibroadenoma tissues as well as the relationship of lymphatic metastasis and prognosis with breast carcinoma.Methods The expressions of VEGF-C and CXCR4 were detected by immunohistochemical method in 72 cases of breast infiltrating carcinoma and 15 cases of breast fibroadenoma tissues.Results The positive rate of VEGF-C and CXCR4 in breast carcinoma was 76.4% and 58.3%,respectively.The level of VEGF-C and CXCR4 expressions was significantly higher in breast infiltrating carcinoma than in breast fibroadenoma tissues(P<0.01).VEGF-C and CXCR4 expressions were significantly correlated with histological grade,clinical stage,lymphatic vessel invasion and lymph node metastasis(P<0.01),but not with age,tumor size or hormone receptor(ER/PR) status(P>0.05).Conclusion VEGF-C and CXCR4 may play a crucial role in lymphatic vessel invasion and lymph node metastasis in breast cancer.