乙型肝炎病毒B、C基因型与乙肝临床特征的相关性

Correlation of hepatitis B virus B and C genotypes with clincial manifestations of hepatitis B

目的探讨乙型肝炎病毒(HBV)B、C基因型与乙肝临床表现与转归的关系。方法对300例乙肝患者进行B、C基因型检测,比较这两种基因型的临床差异,并对影响乙肝的各种因素进行Logistic回归分析。结果在肝硬化、肝癌组中C基因型构成比和HBeAg阳性率显著高于B型(P分别为0、0.01);两种基因型在患者年龄、性别、丙氨酸氨基转移酶(ALT)水平及HBV含量上的差异无统计学意义(P>0.05);Logistic回归分析表明,C基因型肝癌的发生率是B型的5.43倍(OR=5.43,P=0.01)。结论 HBV基因型是乙肝临床转归的重要因素之一。与B基因型比较,C型HBeAg阴转率较低,更容易导致严重的肝病。

Objective To investigate the relationship of hepatitis B virus(HBV) B and C genotypes with clinical manifestations and outcome of hepatitis B. Methods We tested HBV B and C genotypes in 300 patients with hepatitis B,compared their clinical differences,and made a logistic regression analysis of the factors that affected hepatitis B. Results In liver cirrhosis and hepatocellular carcinoma groups,HBeAg positive rate of HBV C genotype was significantly higher than that of HBV B(P=0 and 0.01,respectively).No significant differences were found in age,sex,alanine aminotransferase(ALT) level and HBV loads between the two genotypes(P>0.05).Logistic regression analysis showed that the incidence rate of hepatocellular carcinoma in HBV C genotype was 5.43 times that in B genotype(OR=5.43,P=0.01). Conclusion HBV genotype is an important factor for the outcome of hepatitis B.Compared with HBV B genotype,HBV C genotype has a lower HBeAg negative rate,which induces severe liver diseases more easily.