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Cathepsin B antisense oligodeoxynucleotide suppresses invasive potential of MG-63 cells

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摘要 Objective To study the biological effects of cathepsin B phosporothioated antisense oligodeoxynucleotide on human osteosarcoma cell line MG-63 after transfection.Methods A 18-mer phosphorothioate antisense oligodeoxynucleotide(ASODN)targeted against the cathepsin B mRNA was transfected into the human osteosarcoma cell line MG-63 by lipofectamine 2000.The sense and nonsense oligodeoxynucleotides to cathepsin B and blank vector were used as controls.The expression of cathepsin B mRNA was examined by RT-PCR an...
出处 《Journal of Pharmaceutical Analysis》 SCIE CAS 2008年第2期100-103,118,共5页 药物分析学报（英文版）
基金 Guangxi Science Funds (No.0342010-2)
分类号 R738 [医药卫生—肿瘤]
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参考文献18

  • 1王亚利,宋天保,王中卫,许琨Journal of Nanjing Medical University,2002(03).
  • 2李开华,蔡宣松,梅炯,郭荻萍.组织蛋白酶B在骨肉瘤中的表达及其与肿瘤侵袭转移的关系[J].中国骨肿瘤骨病,2002,1(1):43-45. 被引量：3
  • 3P. A. Andreasen*,R. Egelund,H. H. Petersen.The plasminogen activation system in tumor growth, invasion, and metastasis[J],2000.
  • 4Lakka SS,Gondi CS,Rao JS.Proteases and glioma angiogene- sisBrain Pathology,2005.
  • 5Nierodzik ML,,Karpatkin S.Thrombininduces tumor growth,me- tastasis,and angiogenesis : Evidence for a thrombin-regulated dor- mant tumor phenotypeCancer Cell,2006.
  • 6Lah TT,Duran Alonso MB,Van Noorden CJ.Antiprotease therapy in cancer : hot or notExpert Opinion on Biological Therapy,2006.
  • 7I m E,Venkatakrishnan A,Kazlauskas A.Cathepsin B regu- lates theintrinsic angiogenic threshold of endothelial cellsMolecular Biology of the Cell,2005.
  • 8Freije J M,Balbin M,Pendas A M,et al.Matrix metalloproteinases and tumor progressionAdvances in Experimental Medicine and Biology,2003.
  • 9Hazen LG,Bleeker FE,Lauritzen B,et al.Comparative localization of cathepsin B protein and activity in colorectal cancerJournal of Histochemistry and Cytochemistry,2000.
  • 10LI Kaihua,CAI Xuansong,MEI Jiong,et al. Department of Orthopaedics,General Army Hospital,Jinan Military Region PLA,Jinan 250031,China.Expression of cathepsin B in osteosarcoma and its relationship with tumor metastasisChinese Journal of Bone Tumor and Bone Disease,2002.

二级参考文献8

  • 1[2]Chambers AF, Matrsisian LM. Changing views of the role of matrix metalloproteinase in metatasis. J Natl Cancer Inst, 1997,89:1260.
  • 2[3]Goel A,Chauhan SS.Role of proteases in tumor invasion and metastasis.Indian J Exp Biol, 1997,35:353.
  • 3[4]Haechel C,Ayala AG,Radig K,et al. Protease expression in dedifferenti aed parosteal osteosarcoma. Arch Pathol Lab Med, 1999,123:213 - 221.
  • 4李开华,蔡宣松,梅炯,等.uPA在骨肉瘤中的表达及其与肿瘤侵袭转移的关系[J].中国肿瘤临床与康复,2000,(7):8-10.
  • 5[6]Liotta LA, Tryggvasion K, Garbisa S. Metastic potential correlates with en zymatic degradation of basement membrane collagen. Nature, 1980,284:67.
  • 6[7]Khan A, Krishna M, Baker SP, et al. Cathepsin B expression and its corre lation with tumor- associated laminin and tumor progression in gastric cancer. Arch Pathol Lab Med, 1998,122:172.
  • 7[8]Canterno D, Friess H, Deflorin J, et al. Enhanced expression of uPA and its receptor in pancreatic carcinoma. Br J Cancer, 1997,75:388.
  • 8马忠泰.创造条件,推进骨肉瘤大剂量综合化疗的规范化[J].中华骨科杂志,1999,19(1):5-6. 被引量：31

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Journal of Pharmaceutical Analysis
2008年 第2期

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