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The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma 被引量：1

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摘要 Objective To determine the role of interleukin-8(IL-8)produced by tumor induced fibroblasts in the development of cutaneous melanoma.Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts(MF)by co-culture in vitro.MF was monitored by morphology and immunophenotype for a-SMA.The level of IL-8 was detected by ELISA.The effect on B16 cell proliferation rate was estimated using MTT method in vitro.Melanoma implanting model was constructed in C57 mice.Results L929...
出处 《Journal of Pharmaceutical Analysis》 SCIE CAS 2008年第2期128-133,共6页 药物分析学报（英文版）
分类号 R739.5 [医药卫生—肿瘤]
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参考文献11

  • 1Claudio Brigati,Douglas M. Noonan,Adriana Albini,Roberto Benelli.Tumors and inflammatory infiltrates: Friends or foes?[J].Clinical and Experimental Metastasis.2002(3)
  • 2Des moulire A,,Guyot C,Gabbiani G.The stroma reaction myofibroblast :a key player inthe control of tumor cell behav- ior[].The International Journal of Developmental Biology.2004
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  • 9Smith T J.Insights into the role of fibroblasts in human auto-immune diseases[].Clinical and Experimental Immunology.2005
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Journal of Pharmaceutical Analysis
2008年 第2期

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