Pd催化下Suzuki偶联反应合成5'-硝基-[2,2'-联噻吩]-5-甲醛

Synthesis of 5'-Nitro-[2,2'-bithiophene]-5-carbaldehyde by Pd-catalyzed Suzuki Coupling Reaction

以2-溴-5-硝基噻吩(BNT)和5-甲酰基-2-噻吩硼酸(FTBA)为原料,通过Suzuki偶联反应合成了5'-硝基-[2,2'-联噻吩]-5-甲醛,考察了碱、溶剂、催化剂及加料顺序对该Suzuki偶联反应的影响。结果显示:优化条件为以1,2-二甲氧基乙烷(DME)为溶剂,氟化钠为碱,Pd/C为催化剂,一锅加料。

5'-Nitro-[2,2'-bithiophene]-5-carbaldehyde was synthesized via Suzuki coupling reaction using 5-nitro-2-bromothiophene and 5-formyl-2-thiopheneboronic acid as the starting materials.The influences of various bases,solvents,catalysts and addition sequence of materials on the coupling reaction were investigated.The results showed that the optimum reaction conditions were using DME as the solvent,NaF as the base,Pd/C as the catalyst and all were in one-pot.