黄单胞菌毒性因子调控的研究进展

Advantages in Regulation of Xanthomonas Virulence Factors

黄单胞属植物病原细菌寄主非常广泛,能引起许多种重要经济作物发生病害。黄单胞菌在寄主组织内的侵染和繁殖取决于分泌的多糖、脂多糖、吸附素和III型分泌系统等毒性因子。细菌毒性因子的协调表达是通过群体感应途径、双组分系统和Clp、Zur、FhrR、HrpX和HpaR等转录后调控因子精细调控的。此外,毒力基因表达还受RNA结合蛋白RsmA转录后控制。在本综述中,我们对黄单胞菌控制分泌毒性因子的调控网络的研究进展进行了概括。

Plant pathogenic bacteria of the genus Xanthomonas infect a wide range of host plants and are responsible for important crop plant diseases worldwide.Infection and multiplication of bacterial in the host tissue often rely on the virulence factors secreted including polysaccharides,LPS,adhesins,and type III secretion system.The coordinated expression of bacterial virulence factors is orchestrated by quorum-sensing pathways,multiple two-component systems and transcriptional regulators such as Clp,Zur,FhrR,HrpX and HpaR.In addition,virulence gene expression is post-transcriptionally controlled by the RNA-binding protein RsmA.In this review,we summarize the current advantages on regulatory networks which control secreted virulence factors from Xanthomonas species.