高通量透析对于维持性血液透析患者营养及血脂的影响

Effect of high flux hemodialysis on nutrition and lipid metabolism in maintenance hemodialysis patients

目的研究高通量透析对于维持性血液透析(MHD)患者营养及血脂的影响。方法 :将60名MHD患者随机分为高通量透析(high flux hemo dialysis,HFHD)组和低通量透析(low flux hemo dialysis,LFHD)组,治疗6个月,观察两组患者营养和血脂的变化。结果治疗6个月后,HFHD组改良定量主观整体评分、红细胞生成素(EPO)用量、β2微球蛋白(β2MG)、超敏C反应蛋白(hsCRP)、全段甲状旁腺激素(iPTH)、三酰甘油(TG)及载脂蛋白CIII较LFHD组均有下降(均P<0.05),白蛋白和胰岛素样生长因子-1(IGF-1)升高(P<0.05)。结论高通量透析能改善MHD患者的营养及血脂状况。

Objective To investigate the effect of high flux hemodialysis on nutrition and lipid metabolism in maintenance hemodialysis (MHD) patients. Methods A total of 60 MHD patients were randomly divided into two groups: high flux hemodialysis (HFHD) group, and low flux hemodialysis (LFHD) group. The treatment lasted for 6 months. Changes of the parameters for nutrition and lipid metabolism were observed before and after the treatment in the two groups. Results After 6 months, the Modified Quantitative Subjective Global Assessment score, EPO dose,β2-MG, hsCRP, iPTH, TG and apolipoprotein CIII were significantly lower in HFHD group than in LFHD group, and than in HFHD group before the treatment (P<0.05), while ALB and IGF-1 were significantly higher (P<0.05) in HFHD group. Conclusions High flux hemodialysis can improve nutritional status and dyslipidema in MHD patients.