卡托普利对野百合碱诱发肺动脉高压的影响(英文)

Effect of captopril on monocrotaline-induced pulmonary hypertension

目的 探讨卡托普利 (CPT)对野百合碱 (MCT)诱发大鼠慢性炎性肺动脉高压的影响。方法 将33只雄性Wister大鼠随机分为正常对照组、肺动脉高压模型组、CPT治疗组 ,每组 11只。予MCT(5 0mg/kg)复制大鼠肺动脉高压模型后 ,分别给CPT组及模型组大鼠连续灌胃CPT 2 5mg/ (kg·d)或等量生理盐水2 1d ,采用改良右心导管术测定肺血流动力学参数 ,以非平衡法测定静脉血浆内皮素 - 1(ET - 1)水平 ;处死大鼠后 ,称量肺湿重 (wW )、右心室自由壁 (RV)和左心室加室间隔 (LV +S)重 ,计算右心肥厚指数 (RV/LV +S)。结果 CPT能明显降低肺动脉高压模型大鼠的平均肺动脉压、wW、RV/LV +S及血浆ET - 1水平 (P <0 .0 5 ,或P <0 .0 1)。结论 长期使用CPT能有效降低MCT所致肺动脉高压 ,改善心功能 ,其作用机制可能与显著降低血浆ET - 1水平有关。

Objective:To investigate the effect of captopril on monocrotaline-induced pulmonary hypertension in rats. Methods:Adult male Waister rats were given a single dose of monocrotaline(50 mg/kg) to induce the mold of pulmoanry hypertension.33 cases were randmonly divided into normal control group,mold group and captopril treatment group( n =11).Then treated with gastric infusion of normal saline,captopril respectively for 21 days. The parameter of pulmonary hemodynamics was monitored by Gould 3 400 polygrph system through the cannulation of polyvinyl tube. Right ventricle and left ventricle added with interventricular septum weight ratio,the lung wet weight were measured. The level of plasma endothetin-1 was determined by the method of nonequilibrium.Results: Captopril significantly inhibited the progression of pulmonary artery pressure( P <0.01).It decreased the right heart index, and reduced the lung wet weight and the level of plasma endothelin-1 ( P <0.05,or P <0,01 ).Conclusions:Captopril is able to reduce the pulmonary hypertension and improve the heart function. Its mechanisms may be related to reducing the level of plasma endothelin-1.